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Functional Cognitive Disorder

Diagnosis, Treatment, and Differentiation from Secondary Causes of Cognitive Difficulties
Published:March 15, 2023DOI:https://doi.org/10.1016/j.ncl.2023.02.004

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      References

        • Larner A.J.
        Impact of the National Dementia Strategy in a neurology-led memory clinic: 5-year data.
        Clin Med. 2014; 14: 216
        • Ball H.A.
        • McWhirter L.
        • Ballard C.
        • et al.
        Functional cognitive disorder: dementia’s blind spot.
        Brain. 2020; 143: 2895-2903
        • Bailey C.
        • Poole N.
        • Blackburn D.J.
        Identifying patterns of communication in patients attending memory clinics: a systematic review of observations and signs with potential diagnostic utility.
        Br J Gen Pract. 2018; 68: e123-e138
        • Larner A.J.
        Functional Cognitive Disorders (FCD): how is metacognition involved?.
        Brain Sci. 2021; 11: 1082
        • McWhirter L.
        • Ritchie C.
        • Stone J.
        • et al.
        Functional cognitive disorders: a systematic review.
        Lancet Psychiatr. 2020; 7: 191-207
        • Elsey C.
        • Drew P.
        • Jones D.
        • et al.
        Towards diagnostic conversational profiles of patients presenting with dementia or functional memory disorders to memory clinics.
        Patient Educ Counsel. 2015; 98: 1071-1077
        • Pennington C.
        • Newson M.
        • Hayre A.
        • et al.
        Functional cognitive disorder: what is it and what to do about it?.
        Practical Neurol. 2015; 15: 436-444
        • Pennington C.
        • Ball H.
        • Swirski M.
        Functional cognitive disorder: diagnostic challenges and future directions.
        Diagnostics. 2019; 9: 131
        • Teodoro T.
        • Edwards M.J.
        • Isaacs J.D.
        A unifying theory for cognitive abnormalities in functional neurological disorders, fibromyalgia and chronic fatigue syndrome: systematic review.
        J Neurol Neurosurg Psychiatry. 2018; 89: 1308-1319
        • Stone J.
        • Pal S.
        • Blackburn D.
        • et al.
        Functional (Psychogenic) cognitive disorders: a perspective from the neurology clinic.
        J Alzheimers Dis. 2015; 48 (S5–s17)
        • Hallett M.
        • Aybek S.
        • Dworetzky B.A.
        • et al.
        Functional neurological disorder: new subtypes and shared mechanisms.
        Lancet Neurol. 2022; 21: 537-550
        • Dunne R.A.
        • Aarsland D.
        • O’Brien J.T.
        • et al.
        Mild cognitive impairment: the manchester consensus.
        Age Ageing. 2020; 50: 72-80
        • McKhann G.M.
        • Knopman D.S.
        • Chertkow H.
        • et al.
        The diagnosis of dementia due to Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease.
        Alzheimers Dement. 2011; 7: 263-269
        • Bailey C.
        • Bell S.M.
        • Blackburn D.M.
        How the UK describes functional memory symptoms.
        Psychogeriatrics. 2017; 17: 336-337
        • Bertens D.
        • Vos S.
        • Kehoe P.
        • et al.
        Use of mild cognitive impairment and prodromal AD/MCI due to AD in clinical care: a European survey.
        Alzheimer's Res Ther. 2019; 11 ([Internet]): 74
        • Roberts J.S.
        • Karlawish J.H.
        • Uhlmann W.R.
        • et al.
        Mild cognitive impairment in clinical care: a survey of American Academy of Neurology members.
        Neurology. 2010; 75: 425-431
        • Bhome R.
        • McWilliams A.
        • Price G.
        • et al.
        Metacognition in functional cognitive disorder.
        Brain Communications. 2022; 4: fcac041
        • Larner A.
        Metacognition in functional cognitive disorder: contradictory or convergent experimental results?.
        Brain Communications. 2022; 4: fcac138
        • Wakefield S.J.
        • Blackburn D.J.
        • Harkness K.
        • et al.
        Distinctive neuropsychological profiles differentiate patients with functional memory disorder from patients with amnestic-mild cognitive impairment.
        Acta Neuropsychiatr. 2018; 30: 90-96
        • Frodl T.
        Do (epi)genetics impact the brain in functional neurologic disorders?.
        Handb Clin Neurol. 2016; 139: 157-165
        • Larner A.J.
        Subjective memory complaints: is family history of dementia a risk factor?.
        J Neurol Sci. 2013; 333: e295
        • McWhirter L.
        • Ritchie C.
        • Stone J.
        • et al.
        Identifying functional cognitive disorder: a proposed diagnostic risk model.
        CNS Spectr. 2021; 27: 754-763
        • Bhome R.
        • Huntley J.D.
        • Price G.
        • et al.
        Clinical presentation and neuropsychological profiles of functional cognitive disorder patients with and without co-morbid depression.
        Cogn Neuropsychiatry. 2019; 24: 152-164
        • Reuber M.
        • Blackburn D.J.
        • Elsey C.
        • et al.
        An interactional profile to assist the differential diagnosis of neurodegenerative and functional memory disorders.
        Alzheimer Dis Assoc Disord. 2018; 32: 197-206
        • Mirheidari B.
        • Blackburn D.
        • Harkness K.
        • et al.
        Toward the automation of diagnostic conversation analysis in patients with memory complaints.
        J Alzheimers Dis. 2017; 58: 373-387
        • Haussmann R.
        • Mayer-Pelinski R.
        • Borchardt M.
        • et al.
        Extrinsic and intrinsic help-seeking motivation in the assessment of cognitive decline.
        Am J Alzheimers Dis Other Demen. 2018; 33: 215-220
        • Larner A.J.
        Neurological signs of possible diagnostic value in the cognitive disorders clinic.
        Practical Neurol. 2014; 14: 332-335
        • Bharambe V.
        • Larner A.J.
        Functional cognitive disorders: demographic and clinical features contribute to a positive diagnosis.
        Neurodegener Dis Manag. 2018; 8: 377-383
        • Then F.S.
        • Luck T.
        • Angermeyer M.C.
        • et al.
        Education as protector against dementia, but what exactly do we mean by education?.
        Age Ageing. 2016; 45: 523-528
        • Ball H.A.
        • Swirski M.
        • Newson M.
        • et al.
        Differentiating functional cognitive disorder from early neurodegeneration: a clinic-based study.
        Brain Sci. 2021; 11: 800
        • Aarts S.
        • van den Akker M.
        • Hajema K.J.
        • et al.
        Multimorbidity and its relation to subjective memory complaints in a large general population of older adults.
        Int Psychogeriatr. 2011; 23: 616-624
        • van Maurik I.S.
        • Vos S.J.
        • Bos I.
        • et al.
        Biomarker-based prognosis for people with mild cognitive impairment (ABIDE): a modelling study.
        Lancet Neurol. 2019; 18: 1034-1044
        • Petersen R.C.
        • Lopez O.
        • Armstrong M.J.
        • et al.
        Practice guideline update summary: mild cognitive impairment: report of the guideline development, dissemination, and implementation subcommittee of the american academy of neurology.
        Neurology. 2018; 90: 126-135
        • Pai M.-C.
        • Wu C.-C.
        • Hou Y.-C.
        • et al.
        Evidence of plasma biomarkers indicating high risk of dementia in cognitively normal subjects.
        Sci Rep. 2022; 12: 1192
        • Dubois B.
        • Villain N.
        • Frisoni G.B.
        • et al.
        Clinical diagnosis of Alzheimer's disease: recommendations of the International Working Group.
        Lancet Neurol. 2021; 20: 484-496
        • Striepens N.
        • Scheef L.
        • Wind A.
        • et al.
        Volume loss of the medial temporal lobe structures in subjective memory impairment.
        Dement Geriatr Cogn Disord. 2010; 29: 75-81
        • Ferreira D.
        • Falahati F.
        • Linden C.
        • et al.
        A 'disease severity index' to identify individuals with subjective memory decline who will progress to mild cognitive impairment or dementia.
        Sci Rep. 2017; 7: 44368
        • van Tol M.-J.
        • van der Wee N.J.A.
        • van den Heuvel O.A.
        • et al.
        Regional brain volume in depression and anxiety disorders.
        Arch Gen Psychiatr. 2010; 67: 1002-1011
        • Jansen W.J.
        • Handels R.L.
        • Visser P.J.
        • et al.
        The diagnostic and prognostic value of neuropsychological assessment in memory clinic patients.
        J Alzheimers Dis. 2017; 55: 679-689
        • McWhirter L.
        • Ritchie C.W.
        • Stone J.
        • et al.
        Performance validity test failure in clinical populations-a systematic review.
        J Neurol Neurosurg Psychiatry. 2020; 91: 945-952
        • Schmidtke K.
        • Pohlmann S.
        • Metternich B.
        The syndrome of functional memory disorder: definition, etiology, and natural course.
        Am J Geriatr Psychiatr. 2008; 16: 981-988
        • Ganguli M.
        • Jia Y.
        • Hughes T.F.
        • et al.
        Mild cognitive impairment that does not progress to dementia: a population-based study.
        J Am Geriatr Soc. 2019; 67: 232-238
        • Canevelli M.
        • Grande G.
        • Lacorte E.
        • et al.
        Spontaneous reversion of mild cognitive impairment to normal cognition: a systematic review of literature and meta-analysis.
        J Am Med Dir Assoc. 2016; 17: 943-948
        • Mcwhirter L.
        • King L.
        • McClure E.
        • et al.
        The frequency and framing of cognitive lapses in healthy adults.
        CNS Spectr. 2021; 27: 331-338
        • Stone J.
        • Edwards M.
        Trick or treat? Showing patients with functional (psychogenic) motor symptoms their physical signs.
        Neurology. 2012; 79: 282-284
        • Poole N.A.
        • Cope S.R.
        • Bailey C.
        • et al.
        Functional cognitive disorders: identification and management.
        BJPsych Adv. 2019; 25: 342-350
        • Metternich B.
        • Schmidtke K.
        • Härter M.
        • et al.
        [Development and evaluation of a group therapy for functional memory and attention disorder].
        Psychother Psychosom Med Psychol. 2010; 60: 202-210
        • Youn J.H.
        • Lee J.Y.
        • Kim S.
        • et al.
        Multistrategic memory training with the metamemory concept in healthy older adults.
        Psychiatry Investig. 2011; 8: 354-361
        • Freeburn J.
        Speech therapy: being understood clearly.
        in: LaFaver K. Maurer C.W. Nicholson T.R. Functional Movement disorder: an Interdisciplinary case-based approach. Springer International Publishing, Cham2022: 341-352
        • Carpenter J.
        • Sherman M.T.
        • Kievit R.A.
        • et al.
        Domain-general enhancements of metacognitive ability through adaptive training.
        J Exp Psychol Gen. 2019; 148: 51-64
        • Bhome R.
        • McWilliams A.
        • Huntley J.D.
        • et al.
        Metacognition in functional cognitive disorder- a potential mechanism and treatment target.
        Cogn Neuropsychiatry. 2019; 24: 311-321
        • Bhome R.
        • Berry A.J.
        • Huntley J.D.
        • et al.
        Interventions for subjective cognitive decline: systematic review and meta-analysis.
        BMJ Open. 2018; 8: e021610