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Dysautonomia

Diagnosis and Management
Published:October 31, 2022DOI:https://doi.org/10.1016/j.ncl.2022.08.002

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      References

        • Kornum D.S.
        • Terkelsen A.J.
        • Bertoli D.
        • et al.
        Assessment of Gastrointestinal Autonomic Dysfunction: Present and Future Perspectives.
        J Clin Med. 2021; 10https://doi.org/10.3390/jcm10071392
        • Palma J.A.
        • Norcliffe-Kaufmann L.
        • Kaufmann H.
        Diagnosis of multiple system atrophy.
        Auton Neurosci Basic Clin. 2018; 211: 15-25
        • Raj S.R.
        • Guzman J.C.
        • Harvey P.
        • et al.
        Canadian Cardiovascular Society Position Statement on Postural Orthostatic Tachycardia Syndrome (POTS) and Related Disorders of Chronic Orthostatic Intolerance.
        Can J Cardiol. 2020; 36: 357-372
        • Sheldon R.S.
        • Grubb II, B.P.
        • Olshansky B.
        • et al.
        2015 Heart Rhythm Society Expert Consensus Statement on the Diagnosis and Treatment of Postural Tachycardia Syndrome, Inappropriate Sinus Tachycardia, and Vasovagal Syncope.
        Heart Rhythm. 2015; 12: e41-e63
        • Freeman R.
        • Wieling W.
        • Axelrod F.B.
        • et al.
        Consensus statement on the definition of orthostatic hypotension, neurally mediated syncope and the postural tachycardia syndrome.
        Clin Auton Res. 2011; 21: 69-72
        • Jeanmonod R.
        • Sahni D.
        • Silberman M.
        Vasovagal Episode.
        in: StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL)2022 (Available at:)
        • Verrotti A.
        • Prezioso G.
        • Scattoni R.
        • et al.
        Autonomic Neuropathy in Diabetes Mellitus.
        Front Endocrinol. 2014; 5 (Available at:)
        • Vinik A.I.
        • Ziegler D.
        Diabetic Cardiovascular Autonomic Neuropathy.
        Circulation. 2007; 115: 387-397
        • Axelrod F.B.
        Hereditary sensory and autonomic neuropathies. Familial dysautonomia and other HSANs.
        Clin Auton Res. 2002; 12: I2-I14
        • Kaur D.
        • Tiwana H.
        • Stino A.
        • et al.
        Autonomic neuropathies.
        Muscle Nerve. 2021; 63: 10-21
        • Osztovits J.
        • Horvath E.
        • Tax J.
        • et al.
        Reversible autonomic dysfunction during antiviral treatment in patients with chronic hepatitis C virus infection: Anti-HCV therapy and autonomic function.
        Hepat Mon. 2011; 11: 114-118
        • Saperstein D.S.
        Small Fiber Neuropathy.
        Neurol Clin. 2020; 38: 607-618
        • Raasing L.R.M.
        • Vogels O.J.M.
        • Veltkamp M.
        • et al.
        Current View of Diagnosing Small Fiber Neuropathy.
        J Neuromuscul Dis. 2021; 8: 185-207
        • Dani M.
        • Dirksen A.
        • Taraborrelli P.
        • et al.
        Autonomic dysfunction in ‘long COVID’: rationale, physiology and management strategies.
        Clin Med. 2021; 21: e63
        • Baumgartner C.
        • Koren J.
        • Britto-Arias M.
        • et al.
        Epidemiology and pathophysiology of autonomic seizures: a systematic review.
        Clin Auton Res. 2019; 29: 137-150
        • Moseley B.
        • Bateman L.
        • Millichap J.J.
        • et al.
        Autonomic epileptic seizures, autonomic effects of seizures, and SUDEP.
        Epilepsy Behav. 2013; 26: 375-385
        • Eldokla A.M.
        • Ali S.T.
        Autonomic function testing in long-COVID syndrome patients with orthostatic intolerance.
        Auton Neurosci Basic Clin. 2022; 241https://doi.org/10.1016/j.autneu.2022.102997
        • Wu J.S.
        • Yang Y.C.
        • Lu F.H.
        • et al.
        Population-based study on the prevalence and risk factors of orthostatic hypotension in subjects with pre-diabetes and diabetes.
        Diabetes Care. 2009; 32: 69-74
        • Mu F.
        • Jiao Q.
        • Du X.
        • et al.
        Association of orthostatic hypotension with Parkinson’s disease: a meta-analysis.
        Neurol Sci. 2020; 41: 1419-1426
        • Brignole M.
        • Moya A.
        • de Lange F.J.
        • et al.
        2018 ESC Guidelines for the diagnosis and management of syncope.
        Eur Heart J. 2018; 39: 1883-1948
        • Freeman R.
        • Abuzinadah A.R.
        • Gibbons C.
        • et al.
        Orthostatic Hypotension: JACC State-of-the-Art Review.
        Spec Focus Issue Blood Press. 2018; 72: 1294-1309
        • Mendoza-Velásquez J.J.
        • Flores-Vázquez J.F.
        • Barrón-Velázquez E.
        • et al.
        Autonomic Dysfunction in α-Synucleinopathies.
        Front Neurol. 2019; 10 (Available at:)
        • Allen K.J.
        • Leslie S.W.
        Autonomic Dysreflexia.
        in: StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL)2022: 1-6 (Available at:)
        • Wu B.
        • Wang X.
        • Zhang J.H.
        Cardiac Damage After Subarachnoid Hemorrhage.
        Acta Neurochir Suppl. 2011; 110/1: 215-218
        • Giammello F.
        • Cosenza D.
        • Casella C.
        • et al.
        Isolated Insular Stroke: Clinical Presentation.
        Cerebrovasc Dis. 2020; 49: 10-18
        • Donofrio P.D.
        Guillain-Barré Syndrome.
        Contin Minneap Minn. 2017; 23 (Peripheral Nerve and Motor Neuron Disorders)): 1295-1309
        • Myers M.I.
        • Peltier A.C.
        Uses of Skin Biopsy for Sensory and Autonomic Nerve Assessment.
        Curr Neurol Neurosci Rep. 2012; 13: 323
        • Terkelsen A.J.
        • Karlsson P.
        • Lauria G.
        • et al.
        The diagnostic challenge of small fibre neuropathy: clinical presentations, evaluations, and causes.
        Lancet Neurol. 2017; 16: 934-944
        • Joint Task Force of the EFNS and the PNS
        European Federation of Neurological Societies/Peripheral Nerve Society Guideline on the use of skin biopsy in the diagnosis of small fiber neuropathy. Report of a joint task force of the European Federation of Neurological Societies and the Peripheral Nerve Society.
        J Peripher Nerv Syst. 2010; 15: 79-92
        • Collongues N.
        • Samama B.
        • Schmidt-Mutter C.
        • et al.
        Quantitative and qualitative normative dataset for intraepidermal nerve fibers using skin biopsy.
        PLoS One. 2018; 13: e0191614
        • Gibbons C.H.
        • Freeman R.
        • Bellaire B.
        • et al.
        Synuclein-One study: skin biopsy detection of phosphorylated α-synuclein for diagnosis of synucleinopathies.
        Biomark Med. 2022; 16: 499-509
        • Donadio V.
        Skin nerve α-synuclein deposits in Parkinson’s disease and other synucleinopathies: a review.
        Clin Auton Res. 2019; 29: 577-585
        • Grayston R.
        • Czanner G.
        • Elhadd K.
        • et al.
        A systematic review and meta-analysis of the prevalence of small fiber pathology in fibromyalgia: Implications for a new paradigm in fibromyalgia etiopathogenesis.
        Semin Arthritis Rheum. 2019; 48: 933-940
        • Abrams R.M.C.
        • Simpson D.M.
        • Navis A.
        • et al.
        Small fiber neuropathy associated with SARS-CoV-2 infection.
        Muscle Nerve. 2022; 65: 440-443
        • Waheed W.
        • Carey M.E.
        • Tandan S.R.
        • et al.
        Post COVID-19 vaccine small fiber neuropathy.
        Muscle Nerve. 2021; 64: E1-E2
        • Devigili G.
        • Cazzato D.
        • Lauria G.
        Clinical diagnosis and management of small fiber neuropathy: an update on best practice.
        Expert Rev Neurother. 2020; 20: 967-980
        • Illigens B.M.W.
        • Gibbons C.H.
        Autonomic testing, methods and techniques.
        Handb Clin Neurol. 2019; 160: 419-433
        • Nguyen L.
        • Wilson L.A.
        • Miriel L.
        • et al.
        Autonomic function in gastroparesis and chronic unexplained nausea and vomiting: Relationship with cause, gastric emptying, and symptom severity.
        Neurogastroenterol Motil. 2020; 32: e13810
        • Schol J.
        • Wauters L.
        • Dickman R.
        • et al.
        United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on gastroparesis.
        Neurogastroenterol Motil. 2021; 33: e14237
        • Lenherr S.M.
        • Clemens J.Q.
        Urodynamics With a Focus on Appropriate Indications.
        Urol Clin North Am. 2013; 40: 545-557
        • Yao M.
        • Simoes A.
        Urodynamic testing and interpretation.
        in: StatPearls [Internet]. StatPearls Publishing, Treasure Island (FL)2022: 1-7 (Available at:)
        • Norcliffe-Kaufmann L.
        • Galindo-Mendez B.
        • Garcia-Guarniz A.L.
        • et al.
        Transcranial Doppler in autonomic testing: standards and clinical applications.
        Clin Auton Res Off J Clin Auton Res Soc. 2018; 28: 187-202
        • Figueroa J.J.
        • Cheshire W.P.
        • Claydon V.E.
        • et al.
        Autonomic function testing in the COVID-19 pandemic: an American Autonomic Society position statement.
        Clin Auton Res. 2020; 30: 295-297
        • Thijs R.D.
        • Brignole M.
        • Falup-Pecurariu C.
        • et al.
        Recommendations for tilt table testing and other provocative cardiovascular autonomic tests in conditions that may cause transient loss of consciousness.
        Clin Auton Res. 2021; 31: 369-384
        • Tran J.
        • Hillebrand S.L.
        • Meskers C.G.M.
        • et al.
        Prevalence of initial orthostatic hypotension in older adults: a systematic review and meta-analysis.
        Age Ageing. 2021; 50: 1520-1528
        • Arnold A.C.
        • Ng J.
        • Raj S.R.
        Postural tachycardia syndrome – Diagnosis, physiology, and prognosis.
        Auton Neurosci Basic Clin. 2018; 215: 3-11
        • Raj S.R.
        • Fedorowski A.
        • Sheldon R.S.
        Diagnosis and management of postural orthostatic tachycardia syndrome.
        Can Med Assoc J. 2022; 194: E378
        • Buszko K.
        • Kujawski S.
        • Newton J.L.
        • et al.
        Hemodynamic Response to the Head-Up Tilt Test in Patients With Syncope as a Predictor of the Test Outcome: A Meta-Analysis Approach.
        Front Physiol. 2019; 10: 184
        • Golden E.P.
        • Vernino S.
        Autoimmune autonomic neuropathies and ganglionopathies: epidemiology, pathophysiology, and therapeutic advances.
        Clin Auton Res. 2019; 29: 277-288
        • Poon I.O.
        • Braun U.
        High prevalence of orthostatic hypotension and its correlation with potentially causative medications among elderly veterans.
        J Clin Pharm Ther. 2005; 30: 173-178
        • Fu Q.
        • Levine B.D.
        Exercise and non-pharmacological treatment of POTS.
        Auton Neurosci Basic Clin. 2018; 215: 20-27
        • Wieling W.
        • van Dijk N.
        • Thijs R.D.
        • et al.
        Physical countermeasures to increase orthostatic tolerance.
        J Intern Med. 2015; 277: 69-82
        • Shouman K.
        • Vanichkachorn G.
        • Cheshire W.P.
        • et al.
        Autonomic dysfunction following COVID-19 infection: an early experience.
        Clin Auton Res. 2021; 31: 385-394
        • Ghosh R.
        • Roy D.
        • Sengupta S.
        • et al.
        Autonomic dysfunction heralding acute motor axonal neuropathy in COVID-19.
        J Neurovirol. 2020; 26: 964-966
        • Stefanou M.I.
        • Palaiodimou L.
        • Bakola E.
        • et al.
        Neurological manifestations of long-COVID syndrome: a narrative review.
        Ther Adv Chronic Dis. 2022; 13 (20406223221076890)